Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat
نویسندگان
چکیده
منابع مشابه
Phyllanthus Emblica Extract Protects the Rat Liver Cells Against the Toxicity of Monosodium Glutamate: Experimental Evidence
Background: Monosodium glutamate (MSG), used widely in the food industry, is a threat to the public health. We investigated whether the MSG administration depletes non-enzymatic antioxidants, i.e., vitamins C and E in the liver of Wistar albino rats. We also examined the restorative effect of the ethanolic extract of Phyllanthus emblica (P. emblica). Methods: Wistar albino rats (n=42) were ada...
متن کاملNatural products as safeguards against monosodium glutamate-induced toxicity
Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of severa...
متن کاملParkin overexpression protects retinal ganglion cells against glutamate excitotoxicity
PURPOSE To investigate the role of parkin in regulating mitochondrial homeostasis of retinal ganglion cells (RGCs) under glutamate excitotoxicity. METHODS Rat RGCs were purified from dissociated retinal tissue with a modified two-step panning protocol. Cultured RGCs were transfected with parkin using an adenovirus system. The distribution and morphology of mitochondria in the RGCs were assess...
متن کاملGreen Tea Protects Testes against Atrazine-induced Toxicity in Rat
Background: Atrazine (ATZ) is a common herbicide in agriculture for control of grass and broad-leaved weeds. It persists in the environment and causes reproductive problems in both human and animals. The present study was aimed at protective effect of green tea against ATZ toxicity in the reproductive system of male rats. Methods: The present study was performed in Veterinary School, Shahid ...
متن کاملMystixin-7 Peptide Protects Ionotropic Glutamatergic Mechanisms against Glutamate-Induced Excitotoxicity In Vitro
Hyperactivation of the N-methyl-D-aspartic acid type glutamate receptors (NMDARs) causes glutamate excitotoxicity, a process potentially important for many neurological diseases. This study aims to investigate protective effects of the synthetic corticotrophin-releasing factor-like peptide, mystixin-7 (MTX), on model glutamate-induced excitotoxicity in vitro. The technique online monitoring of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Facultatis Medicae Naissensis
سال: 2019
ISSN: 2217-2521
DOI: 10.2478/afmnai-2019-0004